Harvey Hits #60 was the first Harvey-published comic book to feature the character. Baby Huey, the Baby Giant was the first comic to bear the character's name; spin-offs included Baby Huey in Duckland and Baby Huey and Papa.
Huey's parents, Papa and Mama Duck, always struggled to manage their overgrown son despite his overbearing weight and strength, which often resulted in damage to his family's house or car, injury to Papa, or a threat from Papa's boss to fire him if Huey harmed the boss or caused damage to his home or office. Papa often disparaged Huey (who remained oblivious to his disapproval). Huey's main sidekicks were small identical triplet ducks (who bore a striking resemblance to Donald Duck's nephews. Huey, Dewey and Louie) who resented or mocked Huey for his stupidity and clumsiness but depended on his superhero strength to get them out of trouble.
Characters who appeared in Baby Huey comic books in separate strips included Herman and Katnip and Buzzy the Funny Crow, who was always outsmarting a blue cat (who resembled Katnip) that tried to catch and eat him.
Harvey purchased the rights to all of Famous' original characters in 1959, and Huey continued to appear regularly in Harvey publications until 1972. Huey was rarely seen for nearly two decades afterwards, returning to comics in 1990.
Film Roman produced a new series of Baby Huey cartoons for television in 1994, which aired as The Baby Huey Show for one season. He also starred in a live-action direct-to-video film, Baby Huey's Great Easter Adventure, in 1999.
U.S. President Bill Clinton in a 1993 conversation cited his similarities to Baby Huey: "I'm a lot like Baby Huey. I'm fat. I'm ugly. But if you push me down, I keep coming back." In The Spooktacular New Adventures of Casper segment entitled "Legend of Duh Bigfoot", Baby Huey makes a cameo at the end of that segment.
The documentary Hype! references Baby Huey; by comparing it to different music revolutions that hit different cities at random times.