Greys.Anatomy.S02EP27.Losing My Religion With Izzie on her way up to see Denny before the prom, he dies suddenly due to a blood clot. Izzie is devastated but Alex consoles her and carries her out of the hospital. As she leaves, she admits responsibility to Richard and quits the internship. As the screen fades to black on Season Two, Meredith and Derek ask each other what their encounter means, and final scene shows her looking back and forth between Finn and Derek, unsure of where to turn.