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The second season, titled American Horror Story: Asylum, is about sanity. The story takes place in 1964 and follows the patients, doctors and nuns who occupy the Briarcliff Mental Institution, founded to treat and house the criminally insane. The wardens who run the institution include the stern Sister Jude (Jessica Lange), her protégé Sister Mary Eunice (Lily Rabe) and the founder of the institution, Monsignor Timothy Howard (Joseph Fiennes). The doctors charged with treating the patients at the asylum include psychiatrist Dr. Oliver Thredson (Zachary Quinto) and the sadistic scientist Dr. Arthur Arden (James Cromwell). The patients, many of whom claim to be unjustly institutionalized, include lesbian journalist Lana Winters (Sarah Paulson), accused serial killer Kit Walker (Evan Peters), and alleged murderer Grace (Lizzie Brocheré). Briarcliff's inhabitants are routinely subject to supernatural and scientific influences, including demonic possession and extraterrestrials.
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