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D.N.A. (previously known as And Then There Was Me) is the upcoming fourth studio album from American contemporary R&B singer-songwriter Mario to be released first in the United Kingdom on October 12 by RCA Music Group, then October 13 in the United States, and later in Japan on October 21 by J Records. On the album Mario has worked with previous hitmakers Bryan-Michael Cox as well as new collaborators including The-Dream, Soundz and Jim Jonsin amongst others.

The album's lead single "Break Up" which was written by Sean Garrett and produced by Bangladesh features Garrett and Gucci Mane. Released as a digital-download on April 28, 2009, in the U.S. it has so far peaked at #2 on the Hot R&B/Hip-Hop Chart and #14 on the Billboard Hot 100, becoming Mario's most successful single in five years since, "Let Me Love You". The second single, "Thinkin' About You" was released on September 4, 2009 as a digital-download.